DEXMEDETOMIDINE TRANSDERMAL COMPOSITION, TRANSDERMAL PATCH, AND METHOD FOR PREPARING TRANSDERMAL PATCH AND USE THEREOF

A dexmedetomidine transdermal composition, a transdermal patch, and a method for preparing the transdermal patch and use thereof. The composition comprises dexmedetomidine or a pharmaceutically acceptable salt thereof, propylene glycol, a pressure-sensitive adhesive, and a stabilizer. The propylene glycol serves as a solubilizer of the transdermal composition. After transdermal administration, the concentration of dexmedetomidine in the plasma starts to increase remarkably 8 hours after administration, the blood concentration reaches the maximum and is always maintained at a relatively stable level within 24-72 hours after administration, and meanwhile, in the in vitro transdermal process of the composition, drug release amount in unit time can reach the maximum at 8 hours after administration. Moreover, the stabilizer and the pressure-sensitive adhesive jointly form a skeleton structure, which allows for remarkably improved adhesion performance and better fitting experience of a patient; meanwhile, the produ