CELLULAR MATRIX NERVE GRAFT FOR REPAIRING PERIPHERAL NERVE INJURY AND PREPARATION METHOD THEREFOR
Disclosed are a cellular matrix nerve graft for repairing peripheral nerve injury and a preparation method therefor. The cellular matrix nerve graft comprises an acellular matrix and a scaffold, wherein the acellular matrix is obtained by decellularization of the matrix secreted by stem cells, and t...
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creator | XU, Lingchi WANG, Shanshan QIAN, Tianmei XU, Lai LI, Meiyuan GONG, Leilei GU, Xiaosong SUN, Hualin WANG, Hongkui |
description | Disclosed are a cellular matrix nerve graft for repairing peripheral nerve injury and a preparation method therefor. The cellular matrix nerve graft comprises an acellular matrix and a scaffold, wherein the acellular matrix is obtained by decellularization of the matrix secreted by stem cells, and the acellular matrix is wrapped around the scaffold. With the graft, the defects of autologous nerve transplantation repair can be overcome, and the immunogenicity of allogeneic cell transplantation repair is avoided. The present invention provides a cellular matrix nerve graft conducive to nerve cell proliferation and migration, which can establish a microenvironment conducive to axon growth, thereby achieving the purposes of nerve regeneration and function repair. The present invention provides a feasible solution for clinical treatment of nerve defects.
L'invention concerne un greffon nerveux à matrice cellulaire pour réparer une lésion du nerf périphérique et son procédé de préparation. Le greffon nerveux à matr |
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L'invention concerne un greffon nerveux à matrice cellulaire pour réparer une lésion du nerf périphérique et son procédé de préparation. Le greffon nerveux à matr</description><subject>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</subject><subject>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNzL8KwjAQgPEuDqK-w4GzUFtBOh7tpYmkSTiu_plKkTiJFur7Y4U-gNO3_PiWSV-Sta1FhgaFzRUc8ZmgZlQCyjMwBTRsXA2B2ARNjHZGxp1avgG6CsKPMYrxDhoS7SuQidJ0WCeLR_8c42buKtkqklLv4vDu4jj09_iKn-7iszQ7pPkxK3Lc5_-pL6ONNOI</recordid><startdate>20240222</startdate><enddate>20240222</enddate><creator>XU, Lingchi</creator><creator>WANG, Shanshan</creator><creator>QIAN, Tianmei</creator><creator>XU, Lai</creator><creator>LI, Meiyuan</creator><creator>GONG, Leilei</creator><creator>GU, Xiaosong</creator><creator>SUN, Hualin</creator><creator>WANG, Hongkui</creator><scope>EVB</scope></search><sort><creationdate>20240222</creationdate><title>CELLULAR MATRIX NERVE GRAFT FOR REPAIRING PERIPHERAL NERVE INJURY AND PREPARATION METHOD THEREFOR</title><author>XU, Lingchi ; WANG, Shanshan ; QIAN, Tianmei ; XU, Lai ; LI, Meiyuan ; GONG, Leilei ; GU, Xiaosong ; SUN, Hualin ; WANG, Hongkui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2024037293A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng ; fre</language><creationdate>2024</creationdate><topic>CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES</topic><topic>DISINFECTION, STERILISATION, OR DEODORISATION OF AIR</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL</topic><toplevel>online_resources</toplevel><creatorcontrib>XU, Lingchi</creatorcontrib><creatorcontrib>WANG, Shanshan</creatorcontrib><creatorcontrib>QIAN, Tianmei</creatorcontrib><creatorcontrib>XU, Lai</creatorcontrib><creatorcontrib>LI, Meiyuan</creatorcontrib><creatorcontrib>GONG, Leilei</creatorcontrib><creatorcontrib>GU, Xiaosong</creatorcontrib><creatorcontrib>SUN, Hualin</creatorcontrib><creatorcontrib>WANG, Hongkui</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>XU, Lingchi</au><au>WANG, Shanshan</au><au>QIAN, Tianmei</au><au>XU, Lai</au><au>LI, Meiyuan</au><au>GONG, Leilei</au><au>GU, Xiaosong</au><au>SUN, Hualin</au><au>WANG, Hongkui</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CELLULAR MATRIX NERVE GRAFT FOR REPAIRING PERIPHERAL NERVE INJURY AND PREPARATION METHOD THEREFOR</title><date>2024-02-22</date><risdate>2024</risdate><abstract>Disclosed are a cellular matrix nerve graft for repairing peripheral nerve injury and a preparation method therefor. The cellular matrix nerve graft comprises an acellular matrix and a scaffold, wherein the acellular matrix is obtained by decellularization of the matrix secreted by stem cells, and the acellular matrix is wrapped around the scaffold. With the graft, the defects of autologous nerve transplantation repair can be overcome, and the immunogenicity of allogeneic cell transplantation repair is avoided. The present invention provides a cellular matrix nerve graft conducive to nerve cell proliferation and migration, which can establish a microenvironment conducive to axon growth, thereby achieving the purposes of nerve regeneration and function repair. The present invention provides a feasible solution for clinical treatment of nerve defects.
L'invention concerne un greffon nerveux à matrice cellulaire pour réparer une lésion du nerf périphérique et son procédé de préparation. Le greffon nerveux à matr</abstract><oa>free_for_read</oa></addata></record> |
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subjects | CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL |
title | CELLULAR MATRIX NERVE GRAFT FOR REPAIRING PERIPHERAL NERVE INJURY AND PREPARATION METHOD THEREFOR |
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