TERTIARY AMINE SUBSTITUTED BICYCLIC COMPOUNDS USEFUL AS T CELL ACTIVATORS

Disclosed are compounds of Formula (I): or a salt thereof, wherein: X, Y, R1, R2, R4, R5, and R6 are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutic...

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Bibliographische Detailangaben
Hauptverfasser:	CHUPAK, Louis S, ZHENG, Xiaofan, WARRIER, Jayakumar Sankara, POSY, Shoshana L
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are compounds of Formula (I): or a salt thereof, wherein: X, Y, R1, R2, R4, R5, and R6 are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer. L'invention concerne des composés représentés par la formule (I) : ou un sel de ceux-ci, formule dans laquelle : X, Y, R 1, R 2, R 4, R 5, et R6 sont tels que définis dans la description. L'invention concerne également des procédés d'utilisation de tels composés pour inhiber l'activité de la diacylglycérol kinase alpha (DGKα) et/ou de la diacylglycérol kinase zeta (DGKζ), et des compositions pharmaceutiques comprenant de tels composés. Ces composés sont utiles dans le traitement d'infections virales et de désordres prolifératifs, tels que le cancer.