NON-PHOSPHORYLATED AND NON-UBIQUITINATED CREPT PROTEIN AND USE THEREOF

The present invention relates to a non-phosphorylated and non-ubiquitinated CREPT protein and use thereof. Specifically, the present invention relates to a protein that is obtained by modifying CREPT or a homologous protein thereof. The modification enables the modified protein to maintain a non-pho...

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Bibliographische Detailangaben
Hauptverfasser:	SONG, Yunhao, WANG, Yinyin, CHANG, Zhijie, REN, Fangli
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a non-phosphorylated and non-ubiquitinated CREPT protein and use thereof. Specifically, the present invention relates to a protein that is obtained by modifying CREPT or a homologous protein thereof. The modification enables the modified protein to maintain a non-phosphorylation and non-ubiquitination state so as not to be degraded when the protein is located in eukaryotic cells at the end of the G1 phase or during the G1/S transition phase, so that a double-MCM hexamer cannot be separated, thereby stopping the cell cycle, generating a genome stress response, and finally causing cell death. The present invention also relates to a method for screening a non-phosphorylated and non-ubiquitinated modifier of CREPT, a method for identifying whether a substance is a phosphorylation inhibitor of CREPT, a method for identifying eukaryotic cells at the end of the G1 phase or during the G1/S transition phase by using CREPT, and a method for inducing cancer cell apoptosis to treat cancer