USE OF GENE DELIVERY SYSTEM IN DELIVERING GENE TO MICROGLIAL CELLS

The present invention relates to the field of biotechnology, and specifically, to use of a gene delivery system in delivering a gene to microglial cells, or in preparing a reagent for delivering a gene to microglial cells. The gene delivery system comprises an adeno-associated virus vector. The adeno-associated virus vector is rAAV11, and the adeno-associated virus vector further comprises a gene encoding a marker protein, a promoter, and a neuron expression suppression element. It was first found in the present invention that the adeno-associated virus rAAV11 vector can express a target gene in the microglial cells. On this basis, the rAAV11 vector can be used for carrying a target gene for marking and controlling microglial cells, and can be used as a vector for gene therapy. La présente invention concerne le domaine de la biotechnologie, et plus particulièrement, l'utilisation d'un système d'administration de gènes pour l'administration d'un gène à des cellules microgliales, ou pour la préparation d'un réa