LIPIDS FOR NUCLEIC ACID DELIVERY

LIPIDS FOR NUCLEIC ACID DELIVERY

Provided herein are ionizable lipids, compositions comprising the ionizable lipids, and methods of making and using the same. The ionizable lipids provided herein can be formulated in lipid compositions for the delivery of macromolecules, such as nucleic acids, in vitro, ex vivo, or in vivo. L'...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PARAYATH, Neha Nitin, BOUDIF, Arezki
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Provided herein are ionizable lipids, compositions comprising the ionizable lipids, and methods of making and using the same. The ionizable lipids provided herein can be formulated in lipid compositions for the delivery of macromolecules, such as nucleic acids, in vitro, ex vivo, or in vivo. L'invention concerne des lipides ionisables, des compositions comprenant les lipides ionisables, et des méthodes de fabrication et d'utilisation associées. Les lipides ionisables de l'invention peuvent être préparés sous la forme de compositions lipidiques pour l'administration de macromolécules, telles que des acides nucléiques, in vitro, ex vivo, ou in vivo.