COMPOSITIONS AND METHODS FOR INHIBITION OF RAS

Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e g., inhibiting) KRAS (e.g., KRAS having a G12D mutation)...

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Bibliographische Detailangaben
Hauptverfasser:	XU, Rui, YANG, Yue, ZHANG, Zuhui, WALLACE, Eli, LIGHTSTONE, Felice, LIAO, Tao, PEI, Jun, BRASSARD, Christopher John, CHAN, Albert Hay Wah, WANG, Bin, MACIAG, Anna Elzbieta, TURNER, David Michael, SIMANSHU, Dhirendra Kumar
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e g., inhibiting) KRAS (e.g., KRAS having a G12D mutation) and treating diseases or disorders such as cancers in subjects in need thereof. L'invention concerne des composés, ou des sels, des esters, des tautomères, des promédicaments, des formes zwitterioniques, ou des stéréoisomères de ceux-ci, ainsi que des compositions pharmaceutiques les comprenant. L'invention concerne également des procédés d'utilisation de ceux-ci dans la modulation (par exemple, l'inhibition) de KRAS (par exemple, KRAS ayant une mutation G12D) et le traitement de maladies ou de troubles tels que des cancers chez des sujets en ayant besoin.