NUCLEIC ACID COMPOSITIONS COMPRISING AMPHIPHILIC OLIGO ETHYLENE GLYCOL (OEG)-CONJUGATED COMPOUNDS AND METHODS OF USING SUCH COMPOUNDS AND COMPOSITIONS
The present disclosure relates generally to the field of nucleic acid (such as DNA or RNA, in particular mRNA) compositions comprising an amphiphilic oligo ethylene glycol (OEG)-conjugated compound (as alternative to PEG lipids), to the use of such compositions, in particular for delivering nucleic...
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| creator | GILDERSLEEVE, Griffin OTHERSEN, Olaf APRICENO, Azzurra HEFESHA, Hossam KALLIN, Daniel DONG, Zhengxin MCGEE, Jonathan GANGLUFF, Meike MEHRAVAR, Ehsan |
| description | The present disclosure relates generally to the field of nucleic acid (such as DNA or RNA, in particular mRNA) compositions comprising an amphiphilic oligo ethylene glycol (OEG)-conjugated compound (as alternative to PEG lipids), to the use of such compositions, in particular for delivering nucleic acids to cells of a subject or in therapy, to such amphiphilic OEG-conjugated compounds, and to conjugates of such amphiphilic OEG-conjugated compounds.
La présente invention concerne de manière générale le domaine des compositions d'acide nucléique (telles que d'ADN ou d'ARN, en particulier d'ARNm) contenant un composé conjugué-oligo éthylène glycol (OEG) amphiphile (comme alternative aux lipides PEG), l'utilisation de telles compositions, notamment pour l'administration d'acides nucléiques à des cellules d'un sujet ou en thérapie, de tels composés conjugués-OEG amphiphiles, et des conjugués de tels composés conjugués-OEG amphiphiles. |
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La présente invention concerne de manière générale le domaine des compositions d'acide nucléique (telles que d'ADN ou d'ARN, en particulier d'ARNm) contenant un composé conjugué-oligo éthylène glycol (OEG) amphiphile (comme alternative aux lipides PEG), l'utilisation de telles compositions, notamment pour l'administration d'acides nucléiques à des cellules d'un sujet ou en thérapie, de tels composés conjugués-OEG amphiphiles, et des conjugués de tels composés conjugués-OEG amphiphiles.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS BASED THEREON ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC MACROMOLECULAR COMPOUNDS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; THEIR PREPARATION OR CHEMICAL WORKING-UP ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240208&DB=EPODOC&CC=WO&NR=2024028325A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240208&DB=EPODOC&CC=WO&NR=2024028325A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GILDERSLEEVE, Griffin</creatorcontrib><creatorcontrib>OTHERSEN, Olaf</creatorcontrib><creatorcontrib>APRICENO, Azzurra</creatorcontrib><creatorcontrib>HEFESHA, Hossam</creatorcontrib><creatorcontrib>KALLIN, Daniel</creatorcontrib><creatorcontrib>DONG, Zhengxin</creatorcontrib><creatorcontrib>MCGEE, Jonathan</creatorcontrib><creatorcontrib>GANGLUFF, Meike</creatorcontrib><creatorcontrib>MEHRAVAR, Ehsan</creatorcontrib><title>NUCLEIC ACID COMPOSITIONS COMPRISING AMPHIPHILIC OLIGO ETHYLENE GLYCOL (OEG)-CONJUGATED COMPOUNDS AND METHODS OF USING SUCH COMPOUNDS AND COMPOSITIONS</title><description>The present disclosure relates generally to the field of nucleic acid (such as DNA or RNA, in particular mRNA) compositions comprising an amphiphilic oligo ethylene glycol (OEG)-conjugated compound (as alternative to PEG lipids), to the use of such compositions, in particular for delivering nucleic acids to cells of a subject or in therapy, to such amphiphilic OEG-conjugated compounds, and to conjugates of such amphiphilic OEG-conjugated compounds.
La présente invention concerne de manière générale le domaine des compositions d'acide nucléique (telles que d'ADN ou d'ARN, en particulier d'ARNm) contenant un composé conjugué-oligo éthylène glycol (OEG) amphiphile (comme alternative aux lipides PEG), l'utilisation de telles compositions, notamment pour l'administration d'acides nucléiques à des cellules d'un sujet ou en thérapie, de tels composés conjugués-OEG amphiphiles, et des conjugués de tels composés conjugués-OEG amphiphiles.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjbEKwjAYhLs4iPoOP7joUKipgmtI0ySS5i8mQTqVInESLdRn8XkNpYM4CQd3Bx938-RtPNNcMaBMFcCwqtEqp9DYsZyVVUYArWqponQEUSuBwJ1sNDcchG4YatggF9uUoTl5QR2fprwpLFBTQBV5jBlL8OOi9Uz-MN_ny2R26-5DWE2-SNYld0ymoX-2Yei7a3iEV3tBkpF9Ro45OdBd_h_1AQvoQ2E</recordid><startdate>20240208</startdate><enddate>20240208</enddate><creator>GILDERSLEEVE, Griffin</creator><creator>OTHERSEN, Olaf</creator><creator>APRICENO, Azzurra</creator><creator>HEFESHA, Hossam</creator><creator>KALLIN, Daniel</creator><creator>DONG, Zhengxin</creator><creator>MCGEE, Jonathan</creator><creator>GANGLUFF, Meike</creator><creator>MEHRAVAR, Ehsan</creator><scope>EVB</scope></search><sort><creationdate>20240208</creationdate><title>NUCLEIC ACID COMPOSITIONS COMPRISING AMPHIPHILIC OLIGO ETHYLENE GLYCOL (OEG)-CONJUGATED COMPOUNDS AND METHODS OF USING SUCH COMPOUNDS AND COMPOSITIONS</title><author>GILDERSLEEVE, Griffin ; 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La présente invention concerne de manière générale le domaine des compositions d'acide nucléique (telles que d'ADN ou d'ARN, en particulier d'ARNm) contenant un composé conjugué-oligo éthylène glycol (OEG) amphiphile (comme alternative aux lipides PEG), l'utilisation de telles compositions, notamment pour l'administration d'acides nucléiques à des cellules d'un sujet ou en thérapie, de tels composés conjugués-OEG amphiphiles, et des conjugués de tels composés conjugués-OEG amphiphiles.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS THEIR PREPARATION OR CHEMICAL WORKING-UP VINEGAR WINE |
| title | NUCLEIC ACID COMPOSITIONS COMPRISING AMPHIPHILIC OLIGO ETHYLENE GLYCOL (OEG)-CONJUGATED COMPOUNDS AND METHODS OF USING SUCH COMPOUNDS AND COMPOSITIONS |
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