NUCLEIC ACID COMPOSITIONS COMPRISING AMPHIPHILIC OLIGO ETHYLENE GLYCOL (OEG)-CONJUGATED COMPOUNDS AND METHODS OF USING SUCH COMPOUNDS AND COMPOSITIONS

The present disclosure relates generally to the field of nucleic acid (such as DNA or RNA, in particular mRNA) compositions comprising an amphiphilic oligo ethylene glycol (OEG)-conjugated compound (as alternative to PEG lipids), to the use of such compositions, in particular for delivering nucleic...

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Bibliographische Detailangaben
Hauptverfasser:	GILDERSLEEVE, Griffin, OTHERSEN, Olaf, APRICENO, Azzurra, HEFESHA, Hossam, KALLIN, Daniel, DONG, Zhengxin, MCGEE, Jonathan, GANGLUFF, Meike, MEHRAVAR, Ehsan
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS THEIR PREPARATION OR CHEMICAL WORKING-UP VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure relates generally to the field of nucleic acid (such as DNA or RNA, in particular mRNA) compositions comprising an amphiphilic oligo ethylene glycol (OEG)-conjugated compound (as alternative to PEG lipids), to the use of such compositions, in particular for delivering nucleic acids to cells of a subject or in therapy, to such amphiphilic OEG-conjugated compounds, and to conjugates of such amphiphilic OEG-conjugated compounds. La présente invention concerne de manière générale le domaine des compositions d'acide nucléique (telles que d'ADN ou d'ARN, en particulier d'ARNm) contenant un composé conjugué-oligo éthylène glycol (OEG) amphiphile (comme alternative aux lipides PEG), l'utilisation de telles compositions, notamment pour l'administration d'acides nucléiques à des cellules d'un sujet ou en thérapie, de tels composés conjugués-OEG amphiphiles, et des conjugués de tels composés conjugués-OEG amphiphiles.