SUBSTITUTED BICYCLIC HETEROARYL SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF CANCER

SUBSTITUTED BICYCLIC HETEROARYL SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF CANCER

The invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof; wherein X1 is CR7 or N, X2 is CR8 or N, X3 is CR9 or N and wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the claims, as well as methods of using the compounds for the treatment of neoplas...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KELLENBERGER, Laurenz, WEILER, Sven, ENGEL, Julian, RADIMERSKI, Thomas, GAUCHER, Bérangère
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof; wherein X1 is CR7 or N, X2 is CR8 or N, X3 is CR9 or N and wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the claims, as well as methods of using the compounds for the treatment of neoplastic diseases such as cancer. L'invention concerne des composés de formule (I) et des sels pharmaceutiquement acceptables de ceux-ci ; où X1 est CR7 ou N, X2 est CR8 ou N, X3 est CR9 ou N et où R1, R2, R3, R4, R5, R6, R7, R8 et R9 sont tels que définis dans les revendications, ainsi que des procédés d'utilisation des composés pour le traitement de maladies néoplasiques telles que le cancer.