CARDIAC VALVE WITH EARLY PREFERENTIAL POLARIZATION TOWARDS AN M2 PHENOTYPE POST-IMPLANTATION, AND METHOD OF IMPLANTATION

Cardiac replacement valves that are anti-biofilm and tissue-integrating implantable biomaterial devices that optionally can elute therapeutic ions such as magnesium, silver, copper and/or zinc. In certain embodiments, the devices are hydrophilic due to the presence of ceramic particles such as zeoli...

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Bibliographische Detailangaben
Hauptverfasser:	JOHNS, Derrick, CRUDDEN, Joseph J
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ADDITIVE MANUFACTURING TECHNOLOGY ADDITIVE MANUFACTURING, i.e. MANUFACTURING OFTHREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVEAGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING,STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL PERFORMING OPERATIONS SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDEDFOR SHAPING OR JOINING OF PLASTICS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRANSPORTING WORKING OF PLASTICS WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL
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Beschreibung
Zusammenfassung:	Cardiac replacement valves that are anti-biofilm and tissue-integrating implantable biomaterial devices that optionally can elute therapeutic ions such as magnesium, silver, copper and/or zinc. In certain embodiments, the devices are hydrophilic due to the presence of ceramic particles such as zeolite. In certain embodiments, the devices are subjected to a surface treatment such as a plasma treatment or a corona discharge treatment to enhance the immobilization of integrin-stimulating peptides such as RGD to the biomaterial for cell adhesion enhancement when implanted in a host. Methods of replacing diseased valves in a patient are also disclosed. Valves cardiaques de remplacement constituant des dispositifs de biomatériaux implantables anti-biofilm et à intégration tissulaire, pouvant éventuellement éluer des ions thérapeutiques tels que le magnésium, l'argent, le cuivre et/ou le zinc. Selon certains modes de réalisation, les dispositifs sont hydrophiles en raison de la présence de particules de céramique telles que la zéolithe. Selon certains modes de réalisation, les dispositifs sont soumis à un traitement de surface tel qu'un traitement au plasma ou un traitement par décharge corona afin d'améliorer l'immobilisation des peptides stimulant les intégrines, tels que le RGD, sur le biomatériau pour améliorer l'adhésion des cellules lorsqu'elles sont implantées chez un hôte. L'invention concerne également des procédés de remplacement de valves malades chez un patient.