A PROCESS FOR THE PREPARATION OF EDOXABAN AND ITS INTERMEDIATES

The present invention relates to an efficient and industrially advantageous process for the preparation of Edoxaban of Formula-I or salt thereof. The present invention also relates to a process for preparation of Edoxaban intermediates namely methyl 2-[(5-chloropyridin-2-yl)amino]-2-oxoacetate hydro...

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Bibliographische Detailangaben
Hauptverfasser:	PATEL, Kalpesh Ravajibhai, THAKRAR, Virendra Haridas, BHALANI, Shyam Kishorbhai, SUNDARANI, Kripalsingh Ajitsingh, MEHTA, Tushar Bharatkumar, PRAJAPATI, Nitin Vasantbhai, SUTARIYA, Nirav Bavanjibhai
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to an efficient and industrially advantageous process for the preparation of Edoxaban of Formula-I or salt thereof. The present invention also relates to a process for preparation of Edoxaban intermediates namely methyl 2-[(5-chloropyridin-2-yl)amino]-2-oxoacetate hydrochloride of Formula-II, tert-Butyl [(1R,2S,5S)-2-[[2-[(5-5 chloropyridin-2-yl)amino]-2-oxoacetyl]amino]-5-(dimethylaminocarbonyl)cyclohexyl] carbamate of Formula-IV, and their use for the preparation of Edoxaban or salt thereof. La présente invention concerne un procédé efficace et industriellement avantageux pour la préparation d'edoxaban de formule I ou de ses sels. La présente invention concerne également un procédé de préparation d'intermédiaires d'Edoxaban, à savoir le chlorhydrate de 2-[(5-chloropyridine-2-yl)amino]-2-oxoacétate de méthyle de formule II, le tert-butyl [(1R, 2S,5S)-2-[[2-[(5-5 chloropyridine-2-yl)amino]-2-oxoacétyl]amino]-5-(diméthylaminocarbonyl)cyclohexyl] carbamate de formule IV, et leur utilisation pour la préparation de l'Edoxaban ou d'un de ses sels.