ANTI-TROP2 NANOBODY AND USE THEREOF

Provided are an anti-Trop2 nanobody and use thereof. Also provided is a Trop2-binding molecule, comprising an anti-Trop2 nanobody or an antigen-binding fragment thereof. Complementarity determining regions CDRs of the anti-Trop2 nanobody include CDR1, CDR2, and CDR3 Also provided are a chimeric anti...

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Bibliographische Detailangaben
Hauptverfasser:	XIONG, Qinghui, WANG, Yan, HU, Hongming, JIANG, Pengfei, WANG, Haiying
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Zusammenfassung:	Provided are an anti-Trop2 nanobody and use thereof. Also provided is a Trop2-binding molecule, comprising an anti-Trop2 nanobody or an antigen-binding fragment thereof. Complementarity determining regions CDRs of the anti-Trop2 nanobody include CDR1, CDR2, and CDR3 Also provided are a chimeric antigen receptor comprising the Trop2-binding molecule and an expression cell thereof. L'invention concerne un nanocorps anti-Trop2 et son utilisation. L'invention concerne également une molécule de liaison à Trop2, comprenant un nanocorps anti-Trop2 ou un fragment de liaison à l'antigène de celui-ci. Des régions déterminant la complémentarité CDR du nanocorps anti-Trop2 comprennent CDR1, CDR2 et CDR3. L'invention concerne en outre un récepteur antigénique chimérique comprenant la molécule de liaison à Trop2 et une cellule l'expression. 提供了抗Trop2纳米抗体及其用途。还提供了一种Trop2结合分子，其包含抗Trop2纳米抗体或其抗原结合片段，抗Trop2纳米抗体的互补决定区CDR包含CDR1、CDR2和CDR3。还提供了含有该Trop2结合分子的嵌合抗原受体及其表达细胞。