SALTS OF BELUMOSUDIL, CRYSTALLINE FORMS AND PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR USE IN THE TREATMENT OF CHRONIC GRAFT-VERSUS-HOST DISEASE

The present invention provides novel salts of belumosudil (I) and crystalline forms thereof. Specific salts of belumosudil provided by the present invention include L-malate, acesulfamate, fumarate, maleate, isethionate, malonate, edisylate, citrate, and L-tartrate. Also provided are pharmaceutical...

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Bibliographische Detailangaben
Hauptverfasser:	REY, Allan W, STIRK, Alexander J, SOUZA, Fabio E.S
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides novel salts of belumosudil (I) and crystalline forms thereof. Specific salts of belumosudil provided by the present invention include L-malate, acesulfamate, fumarate, maleate, isethionate, malonate, edisylate, citrate, and L-tartrate. Also provided are pharmaceutical compositions comprising the belumosudil salts and crystalline forms thereof and the use of these salts in the treatment of chronic graft- versus-host disease in a subject suffering therefrom. La présente invention concerne de nouveaux sels de bélumosudil (I) et des formes cristallines de ceux-ci. Les sels spécifiques de bélumosudil fournis par la présente invention comprennent le L-malate, l'acésulfamate, le fumarate, le maléate, l'iséthionate, le malonate, l'édisylate, le citrate et le L-tartrate. L'invention concerne également des compositions pharmaceutiques comprenant les sels de bélumosudil et des formes cristallines de ceux-ci ainsi que l'utilisation de ces sels dans le traitement d'une maladie chronique du greffon contre l'hôte chez un sujet atteint de celle-ci.