SMALL MOLECULES INHIBITORS OF CYCLIC GMP-AMP SYNTHASE (CGAS)

Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: (I) wherein R1, R2, R3, L, X, and Ar are defined in the present disclosure. The compounds are inhibitors of cyclic gmp-amp synthase (cGAS) or CGAS-related cGAMP production, a...

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Bibliographische Detailangaben
Hauptverfasser:	CHIN, Emily, BOOKSER, Brett, LAPOINTE, David, LAIRSON, Luke
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: (I) wherein R1, R2, R3, L, X, and Ar are defined in the present disclosure. The compounds are inhibitors of cyclic gmp-amp synthase (cGAS) or CGAS-related cGAMP production, and they are useful in treating or preventing inflammatory diseases or conditions in a subject. L'invention concerne des composés de formule (I), leurs sels pharmaceutiquement acceptables, et leurs compositions pharmaceutiques : (I) dans laquelle R1, R2, R3, L, X, et Ar sont tels que définis dans la présente description. Les composés sont des inhibiteurs de la production cyclique de gmp-amp synthase (cGAS) ou de cGAMP liée à CGAS, et ils sont utiles dans le traitement ou la prévention de maladies ou d'états inflammatoires chez un sujet.