METHOD FOR PRODUCING URATE OXIDASE-ALBUMIN CONJUGATE USING BCN LINKER AND USE THEREOF

The present application relates to a urate oxidase-albumin conjugate and a method for producing same, the urate oxidase-albumin conjugate being produced by binding albumin with a urate oxidase mutant having an unnatural amino acid site-specifically introduced therein. The urate oxidase-albumin conju...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	KIM, Hyeong Seok, CHO, Jeong Haeng, KIM, Hyun Woo, KIM, Seon Gwan
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present application relates to a urate oxidase-albumin conjugate and a method for producing same, the urate oxidase-albumin conjugate being produced by binding albumin with a urate oxidase mutant having an unnatural amino acid site-specifically introduced therein. The urate oxidase-albumin conjugate of the present application is produced through a linker comprising a bicyclononyne group. La présente demande concerne un conjugué urate oxydase-albumine et son procédé de production, le conjugué urate oxydase-albumine étant produit par liaison d'albumine avec un mutant d'urate oxydase dans lequel un site d'acide aminé non naturel a été spécifiquement introduit. Le conjugué urate oxydase-albumine de la présente demande est produit grâce à un lieur comprenant un groupe bicyclononyne. 본 출원은 위치 특이적으로 비천연아미노산이 도입된 요산산화효소 변이체와 알부민이 결합된, 요산산화효소-알부민 컨쥬게이트 및 이의 제조 방법에 관한 것이다. 본 출원의 요산산화효소-알부민 컨쥬게이트는 비시클로노닌(bicyclononyne) 그룹을 포함하는 링커를 통해 제조된 것을 특징으로 한다.