1,4-DIPHENYL-1 H-INDAZOLE AND 1-PYRIDIN-2-YL-4-PHENYL-1 H-INDAZOLE DERIVATIVES AS PD-1/PD-L1 MODULATORS FOR THE TREATMENT OF CANCER

1,4-DIPHENYL-1 H-INDAZOLE AND 1-PYRIDIN-2-YL-4-PHENYL-1 H-INDAZOLE DERIVATIVES AS PD-1/PD-L1 MODULATORS FOR THE TREATMENT OF CANCER

The present disclosure relates to compounds of Formula (I): The compounds disclosed herein are useful for modulating PD-1 activity, PD-L1 activity (programmed cell death protein 1), and/or the PD-1/PD-L1 interaction and may be used in the treatment of disorders in which PD-1 activity, PD-L1 activity...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: THAVORNSIN, Nopparat, DEESIRI, Sirikan, CHAROENPAKDEE, Chayan, PISITKUN, Trairak, RATTANANGKOOL, Eakkaphon, AMPAWA, Supanan, SRISA, Jakkrit, DUNKOKSUNG, Wilasinee, BURANAPRADITKUN, Supranee, JIRAPONGWATTANA, Niphat, HIRANKARN, Nattiya, UDOMNILOBOL, Udomsak, NALINRATANA, Nonthaneth, PRUEKSARITANONT, Thomayant, RUENGSATRA, Tanachote, SOPONPONG, Jakapun, SONGTHAMMANUPHAP, Songkiat
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present disclosure relates to compounds of Formula (I): The compounds disclosed herein are useful for modulating PD-1 activity, PD-L1 activity (programmed cell death protein 1), and/or the PD-1/PD-L1 interaction and may be used in the treatment of disorders in which PD-1 activity, PD-L1 activity, and/or PD-1/PD-L1 interaction is implicated, such as cancer. Preferred compounds are e.g. 1,4-diphenyl-lH-indazole and 1- pyridin-2-yl-4-phenyl-lH-indazole derivatives of formulae (l-a) and (I- a1): An exemplary compound is e.g.: La présente divulgation concerne des composés de formule (I) : Les composés divulgués sont utiles pour moduler l'activité de PD-1, PD-L1 (protéine 1 de mort cellulaire programmée) et/ou l'interaction PD-1/PD-L1 et peuvent être utilisés dans le traitement de troubles dans lesquels l'activité de PD-1, PD-L1 et/ou l'interaction PD-1/PD-L1 est impliquée, telles que le cancer. Les composés préférés sont par exemple les dérivés de 1,4-diphényl-lH-indazole et de 1-pyridin-2-yl-4-phényl-lH-indazole de formules (l-a) et (I- a1): Un composé donné à titre d'exemple est par exemple :