TARGETED MODULATORS OF JAK3 FOR TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES

TARGETED MODULATORS OF JAK3 FOR TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES

JAK3 inhibitors are described that contain a combination of 2 or more of the following moieties: a cyano-containing Michael acceptor, a l,6-dihydroimidazo[4,5-d]pyrrolo[2,3- b]pyridin, and a targeting factor to increase myeloid cell uptake and exposure. L'invention concerne des inhibiteurs de J...

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Bibliographische Detailangaben
Hauptverfasser: BURNET, Michael, LAUFER, Stefan, LAUX, Julian, GUSE, Jan-Hinrich
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:JAK3 inhibitors are described that contain a combination of 2 or more of the following moieties: a cyano-containing Michael acceptor, a l,6-dihydroimidazo[4,5-d]pyrrolo[2,3- b]pyridin, and a targeting factor to increase myeloid cell uptake and exposure. L'invention concerne des inhibiteurs de JAK3 qui contiennent une combinaison de 2 ou plus des fractions suivantes : un accepteur de Michael contenant un cyano, une 1,6-dihydroimidazo[4,5-d]pyrrolo [2,3-b]pyridine, et un facteur de ciblage pour augmenter l'absorption et l'exposition de cellules myéloïdes.