N-(2-(3-CYANO-2-AZABICYCLO[3.1.0]HEXAN-2-YL)-2-OXOETHYL)- QUINOLINE-4-CARBOXAMIDES

Compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, wherein R2, R3, R5, R6, R7, and R8 are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; use of such compounds and salts to treat or prevent Prolyl endopeptida...

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Bibliographische Detailangaben
Hauptverfasser:	JOHANSSON, Maria, O'MAHONY, Gavin, SWANSON, Marianne, BRÅNALT, Jonas, NORDQVIST, Anneli
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, wherein R2, R3, R5, R6, R7, and R8 are as defined in the specification; pharmaceutical compositions comprising such compounds and salts; use of such compounds and salts to treat or prevent Prolyl endopeptidase fibroblast activation protein (FAP)-mediated conditions; kits comprising such compounds and salts; and methods for manufacturing such compounds and salts. L'invention concerne des composés ayant la structure de formule (I) et leurs sels pharmaceutiquement acceptables, dans laquelle où R2, R3, R5, R6, R7, et R8 ont la signification indiquée dans la description ; des compositions pharmaceutiques comprenant de tels composés et sels ; l'utilisation de tels composés et sels pour traiter ou prévenir des états pathologiques à médiation assurée par la protéine d'activation des fibroblastes (FAP) prolyl-endopeptidase ; des kits comprenant de tels composés et sels ; et des procédés de fabrication de tels composés et sels.