TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS

The present invention relates to compounds that inhibit at least one of KRas wild type, KRas G12A, KRas G12C, KRas G12D, KRas G12R, KRas G12S, KRas G12V, KRas G13D and KRas Q61H, pharmaceutical compositions comprising the compounds and methods of use therefor. La présente invention concerne des comp...

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Bibliographische Detailangaben
Hauptverfasser:	LAWSON, John David, KULYK, Svitlana, SMITH, Christopher Ronald, MARX, Matthew Arnold, IVETAC, Anthony, WANG, Xiaolun
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds that inhibit at least one of KRas wild type, KRas G12A, KRas G12C, KRas G12D, KRas G12R, KRas G12S, KRas G12V, KRas G13D and KRas Q61H, pharmaceutical compositions comprising the compounds and methods of use therefor. La présente invention concerne des composés qui inhibent au moins une mutation parmi KRas de type sauvage, KRas G12A, KRas G12C, KRas G12D, KRas G12R, KRas G12S, KRas G12V, KRas G13D et KRas Q61H, des compositions pharmaceutiques comprenant ces composés et leurs méthodes d'utilisation.