STING AGONIST COMPOUNDS

The present disclosure is related to STING agonists, pharmaceutical compositions thereof, and the use of the agonists and pharmaceutical compositions to induce a STING-mediated immune response and/or to treat diseases and disorders mediated by STING, such as cellular proliferative disorders, includi...

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Bibliographische Detailangaben
Hauptverfasser:	BAGGETT, Scott, GALAN, Adam Antoni, LIU, Wen, ZHU, Xiangwei, BAJJURI, Krishna, SINGH, Ravi Prakash, HU, Huiyong, POLYAKOV, Valery Rostislavovich, MADERNA, Andreas
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure is related to STING agonists, pharmaceutical compositions thereof, and the use of the agonists and pharmaceutical compositions to induce a STING-mediated immune response and/or to treat diseases and disorders mediated by STING, such as cellular proliferative disorders, including, but not limited to, cancer. La présente invention concerne des agonistes de STING, des compositions pharmaceutiques de ceux-ci, et l'utilisation des agonistes et des compositions pharmaceutiques pour induire une réponse immunitaire à médiation par STING et/ou pour traiter des maladies et des troubles médiés par STING, tels que des troubles prolifératifs cellulaires, comprenant, entre autres, le cancer.