CORONAVIRUS S PROTEIN VARIANT AND USE THEREOF

Provided is an S protein variant, which does not contain a complete cytoplasmic tail domain compared to the S protein of a wild-type coronavirus. Further provided are a nucleic acid molecule encoding the S protein variant, and the use of the S protein variant and the nucleic acid molecule in the pre...

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Bibliographische Detailangaben
Hauptverfasser:	LIN, Jinzhong, LU, Jing, TAN, Shudan
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided is an S protein variant, which does not contain a complete cytoplasmic tail domain compared to the S protein of a wild-type coronavirus. Further provided are a nucleic acid molecule encoding the S protein variant, and the use of the S protein variant and the nucleic acid molecule in the preparation of a vaccine. L'invention concerne un variant de protéine S, qui ne contient pas de domaine de queue cytoplasmique complet par rapport à la protéine S d'un coronavirus de type sauvage. L'invention concerne en outre une molécule d'acide nucléique codant pour le variant de protéine S, et l'utilisation du variant de protéine S et de la molécule d'acide nucléique dans la préparation d'un vaccin. 提供了一种S蛋白变体，与野生型冠状病毒的S蛋白相比，其不包含完整的细胞质尾巴结构域。还提供了编码所述S蛋白变体的核酸分子，以及所述S蛋白变体和核酸分子在制备疫苗中的应用。