CRYSTALLINE FORM OF ASPACYTARABINE INTERMEDIATE

The present invention relates to crystalline polymorph Form I of benzyl N2- ((benzyloxy)carbonyl)-N4-(l-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran- 2-yl)-2-oxo-l,2-dihydropyrimidin-4-yl)-L-asparaginate (Compound 1), process of preparation thereof, and uses thereof for the preparat...

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Bibliographische Detailangaben
Hauptverfasser:	LIDOR-HADAS, Ramy, SHUMILOV, Margarita, TESSLER, Shoshanna
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	APPARATUS THEREFOR CHEMISTRY DERIVATIVES THEREOF GENERAL METHODS OF ORGANIC CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS
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Beschreibung
Zusammenfassung:	The present invention relates to crystalline polymorph Form I of benzyl N2- ((benzyloxy)carbonyl)-N4-(l-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran- 2-yl)-2-oxo-l,2-dihydropyrimidin-4-yl)-L-asparaginate (Compound 1), process of preparation thereof, and uses thereof for the preparation of aspacytarabine. La présente invention concerne une forme polymorphe cristalline I de benzyl N2-((benzyloxy)carbonyl)-N4-(1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxyméthyl)tétrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-L-asparaginate (composé 1), son procédé de préparation et ses utilisations pour la préparation d'aspacytarabine.