LONG-ACTING EXENDIN-9-39 AND USE THEREOF IN HYPOGLYCEMIA TREATMENT AND AS DRUG FOR TREATING HYPOGLYCEMIA

Provided are long-acting Exendin-9-39 and a use thereof as a GLP-1 receptor antagonist in hypoglycemia treatment and preparation of a drug for treating hypoglycemia. The long-acting Exendin-9-39 comprises AR-GLP1R-01 and AR-GLP1R-02, AR-GLP1R-01 has a structure as shown in FIG. 2, and AR-GLP1R-02 ha...

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Bibliographische Detailangaben
Hauptverfasser:	WANG, Manchen, LI, Jia, YUAN, Yue, LI, Hushan, LI, Changhong, JIANG, Haowen
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided are long-acting Exendin-9-39 and a use thereof as a GLP-1 receptor antagonist in hypoglycemia treatment and preparation of a drug for treating hypoglycemia. The long-acting Exendin-9-39 comprises AR-GLP1R-01 and AR-GLP1R-02, AR-GLP1R-01 has a structure as shown in FIG. 2, and AR-GLP1R-02 has a structure as shown in FIG. 3. The long-acting Exendin-9-39 can inhibit insulin secretion and increase the blood sugar of a hypoglycemia disease mouse model (SUR1 knockout mouse) by inhibiting a GLP-1 receptor, thereby achieving the effect of treating congenital hyperinsulinism (CHI). L'invention concerne une exendine-9-39 à action prolongée et son utilisation en tant qu'antagoniste du récepteur GLP-1 dans le traitement de l'hypoglycémie et la préparation d'un médicament pour le traitement de l'hypoglycémie. L'exendine-9-39 à action prolongée comprend AR-GLP1R-01 et AR-GLP1R-02, AR-GLP1R-01 a une structure telle que représentée sur la FIG. 2, et AR-GLP1R-02 a une structure telle que représentée sur la FIG. 3. L'