CYCLIC PEPTIDES WITH ANTIBACTERIAL ACTIVITY AGAINST MULTIDRUG RESISTANT (MDR) PATHOGENS

The present invention relates to cyclic peptides of a particular formula (I), X1X2X3X4CX6X7X8PX10X11X12X13CX15X16X17P (SEQ ID NO: 1) (I), fwherein X1 to X17 take several meanings, and X1 and D-Pro at position 18 are linked by a peptide bond; which cyclic peptides are useful as antimicrobial agents....

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Bibliographische Detailangaben
Hauptverfasser:	GIRALT LLEDÓ, Ernest, VILA ESTAPÉ, Jordi, GUARDIOLA BAGAN, Salvador, MARTÍN VILARDELL, Núria, BALLESTÉ DELPIERRE, Clara, MORENO MORALES, Javier
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to cyclic peptides of a particular formula (I), X1X2X3X4CX6X7X8PX10X11X12X13CX15X16X17P (SEQ ID NO: 1) (I), fwherein X1 to X17 take several meanings, and X1 and D-Pro at position 18 are linked by a peptide bond; which cyclic peptides are useful as antimicrobial agents. The invention also relates to particular bicyclic compounds, in which cysteines at positions 5 and 14 are crosslinked by a disulfide bond. The invention also relates to pharmaceutical compositions comprising the said peptides and to the medical applications of the peptides or of the compositions comprising them. La présente invention concerne des peptides cycliques de formule particulière (I), X1X2X3X4CX6X7X8PX10X11X12X13CX15X16X17P (SEQ ID NO : 1) (I), X1 à X17 prenant plusieurs significations, et X1 et D-Pro en position 18 étant liés par une liaison peptidique ; lesdits peptides cycliques étant utiles en tant qu'agents antimicrobiens. L'invention concerne également des composés bicycliques particuliers, les cystéines aux positions 5 et 14 étant réticulées par une liaison disulfure. L'invention concerne en outre des compositions pharmaceutiques comprenant lesdits peptides et des utilisations médicales des peptides ou des compositions les comprenant.