NITROGEN-CONTAINING FIVE-MEMBERED HETEROCYCLIC DERIVATIVES AS CHECKPOINT KINASE 1 INHIBITOR AND USES THEREOF

The present disclosure relates generally to nitrogen-containing five-membered heterocyclic derivatives usefulness in treatment of conditions associated with Checkpoint kinase (CHK), particularly more specifically CHK-1 enzymes. Methods of use, compositions, and method of synthesis are also disclosed...

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Bibliographische Detailangaben
Hauptverfasser:	CAI, Zhang, PANPATIL, Dayanand, MA, Jingjing, KHAN, Pasha M, LIU, Hanlan, WANG, Xiaohui, YAN, Zhiyu, HUANG, Yung-Jen, PUJALA, Brahmam, RUAN, Juxin
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure relates generally to nitrogen-containing five-membered heterocyclic derivatives usefulness in treatment of conditions associated with Checkpoint kinase (CHK), particularly more specifically CHK-1 enzymes. Methods of use, compositions, and method of synthesis are also disclosed. La présente invention concerne de manière générale des dérivés hétérocycliques à cinq chaînons contenant de l'azote utiles dans le traitement d'états associés à la kinase de point de contrôle (CHK), plus spécifiquement à des enzymes de CHK-1. L'invention concerne également des procédés d'utilisation, des compositions et un procédé de synthèse.