METHODS FOR MITIGATING LUNG INJURY IN CONJUNCTION WITH EXPOSURE TO RADIATION AND/OR RADIATION OR RADIOMIMETIC TREATMENTS

METHODS FOR MITIGATING LUNG INJURY IN CONJUNCTION WITH EXPOSURE TO RADIATION AND/OR RADIATION OR RADIOMIMETIC TREATMENTS

Methods and kits for mitigating lung injury in a subject treated with a targeted radiation therapy or otherwise exposed to radiation are described. In particular, an effective amount of a thrombopoietin mimetic, such as RWJ-800088 or romiplostim, is used to mitigate the radiation-induced lung injury...

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Bibliographische Detailangaben
Hauptverfasser: EICHENBAUM, Gary, GUHA, Chandan, ENGLISH, Jeb, YANG, Weng-Leng
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Methods and kits for mitigating lung injury in a subject treated with a targeted radiation therapy or otherwise exposed to radiation are described. In particular, an effective amount of a thrombopoietin mimetic, such as RWJ-800088 or romiplostim, is used to mitigate the radiation-induced lung injury. L'invention concerne des procédés et des kits pour atténuer une lésion pulmonaire chez un sujet traité avec une radiothérapie ciblée ou autrement exposé à un rayonnement. En particulier, une quantité efficace d'un mimétique de thrombopoïétine, tel que le RWJ-800088 ou le romiplostim, est utilisée pour atténuer la lésion pulmonaire induite par rayonnement.