COMPOSITIONS AND METHODS FOR TREATING HEPATITIS D VIRUS (HDV) INFECTION AND ASSOCIATED DISEASES

The present disclosure provides methods for treating hepatitis D virus (HDV) infection and/or an HDV-associated disease using combination therapies, and related kits and compositions for use in such methods. The components of the combination therapies may include one or more of an anti-HBV antibody;...

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Bibliographische Detailangaben
Hauptverfasser:	LAU, Audrey H, GUPTA, Sneha V, CHATTERGOON, Michael A, CLOUTIER, Daniel J, HWANG, Carey K, ELIE, Sophia E
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure provides methods for treating hepatitis D virus (HDV) infection and/or an HDV-associated disease using combination therapies, and related kits and compositions for use in such methods. The components of the combination therapies may include one or more of an anti-HBV antibody; an siRNA that targets an HBV mRNA; and a nucleos(t)ide reverse transcriptase inhibitor (NRTI). La présente divulgation concerne des méthodes de traitement d'une infection par le virus de l'hépatite D (VHD) et/ou d'une maladie associée au VHD à l'aide de polythérapies, ainsi que des kits et des compositions associés destinés à être utilisés dans de telles méthodes. Les composants des polythérapies peuvent comprendre un ou plusieurs éléments parmi un anticorps anti-VHB ; un pARNi qui cible un ARNm de VHB ; et un inhibiteur de transcriptase inverse (NRTI) à base de nucléosides et de nucléotides.