COMPOSITIONS AND METHODS FOR TREATING HEPATITIS B VIRUS (HBV) INFECTION AND HBV-ASSOCIATED DISEASES

COMPOSITIONS AND METHODS FOR TREATING HEPATITIS B VIRUS (HBV) INFECTION AND HBV-ASSOCIATED DISEASES

The present disclosure provides methods for treating HBV infection using combination therapies, and related kits and compositions for use. The components of the combination therapies may include one or more of an anti-HBV antibody; an siRNA that targets an HBV mRNA; interferon-α; and a nucleos(t)ide...

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Bibliographische Detailangaben
Hauptverfasser: LAU, Audrey H, GUPTA, Sneha V, THANAWALA, Vaidehi Jatin, SEU, Lillian, CLOUTIER, Daniel J, HWANG, Carey K, WONG, Rachel
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The present disclosure provides methods for treating HBV infection using combination therapies, and related kits and compositions for use. The components of the combination therapies may include one or more of an anti-HBV antibody; an siRNA that targets an HBV mRNA; interferon-α; and a nucleos(t)ide reverse transcriptase inhibitor (NRTI). La présente divulgation concerne des méthodes de traitement d'une infection par le VHB au moyen de polythérapies, ainsi que des trousses et des compositions associées destinées à être utilisées. Les composants des polythérapies peuvent comprendre un ou plusieurs éléments parmi un anticorps anti-VHB ; un ARNsi qui cible un ARNm de VHB ; un interféron-α ; et un inhibiteur de transcriptase inverse à base de nucléotides (NRTI).