AT2R ANTAGONISTS AND USES THEREOF

AT2R ANTAGONISTS AND USES THEREOF

This invention provides certain piperidine compounds as AT2R antagonists, e.g., compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and X are as defined herein, pharmaceutical compositions thereof, and methods of using the same to treat pain associated with AT...

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Bibliographische Detailangaben
Hauptverfasser: LINESWALA, Jayana Pankajkumar, SHER, Emanuele, THAPA, Bishnu, CHEN, Zhaogen, BEAUCHAMP, Thomas James, CONNER, Scott Eugene, ERICKSON, Jon Andre, GARCIA PAREDES, Maria Cristina, WINNEROSKI, Leonard Larry II
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:This invention provides certain piperidine compounds as AT2R antagonists, e.g., compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and X are as defined herein, pharmaceutical compositions thereof, and methods of using the same to treat pain associated with AT2R activity. La présente invention concerne certains composés de pipéridine en tant qu'antagonistes d'AT2R, par exemple, des composés de formule (I) : ou des sels pharmaceutiquement acceptables de ceux-ci, R1, R2, R3 et X étant tels que définis dans la description, des compositions pharmaceutiques de ceux-ci, et des procédés d'utilisation de ceux-ci pour traiter la douleur associée à l'activité d'AT2R.