AZOLO COMPOUNDS FOR TREATMENT OF FIBROTIC DISEASES

The present invention relates to an azolo compound of Formula (I) for use in the treatment of fibrosis, wherein the azolo compounds normalizes collagen I mRNA-levels of TGFB-activated fibroblasts and reverses collagen production to the normal levels that are seen in fibroblasts that are not stimulat...

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Bibliographische Detailangaben
Hauptverfasser:	VOSS, Edgar, HASENFUSS, Gerd, NYAMSUREN, Gunsmaa, TIETZE, Lutz Friedjahn, MOTHUKU, Shyam Sundar, ZEISBERG, Michael
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to an azolo compound of Formula (I) for use in the treatment of fibrosis, wherein the azolo compounds normalizes collagen I mRNA-levels of TGFB-activated fibroblasts and reverses collagen production to the normal levels that are seen in fibroblasts that are not stimulated. La présente invention concerne un composé azolo de Formule (I) destiné à être utilisé dans le traitement de la fibrose, les composés azolo normalisant les taux d'ARNm de collagène I de fibroblastes activés par TGFB et inversant la production de collagène vers les niveaux normaux qui sont constatés dans des fibroblastes qui ne sont pas stimulés.