PI3Kα INHIBITORS AND METHODS OF USE THEREOF
The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3Kα enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders...
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| creator | MCLEAN, Thomas H FRIDRICH, Cary Griffin PAN, Yue MOHAMED, Tarek RAYNOR, Kevin David BURNIE, Andrew J PERREAULT, Christian BAUM, Erich W SHORTSLEEVES, Kelley C ATIENZA, Bren-Jordan LARIVEE, Alexandre BOEZIO, Alessandro LEPITRE, Thomas DENINNO, Michael Paul KRUEGER, Elaine B THOMSON, Christopher MOUSTAKAS, Demetri T MAERTENS, Gaetan |
| description | The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3Kα enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3Kα signaling with the compounds and compositions of the disclosure.
La présente invention concerne de nouveaux composés et des compositions pharmaceutiques de ceux-ci, et des procédés d'inhibition de l'activité d'enzymes PI3Kα avec les composés et les compositions de l'invention. La présente invention concerne en outre, mais sans s'y limiter, des procédés de traitement de troubles associés à la signalisation de PI3Kα avec les composés et les compositions de l'invention. |
| format | Patent |
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La présente invention concerne de nouveaux composés et des compositions pharmaceutiques de ceux-ci, et des procédés d'inhibition de l'activité d'enzymes PI3Kα avec les composés et les compositions de l'invention. La présente invention concerne en outre, mais sans s'y limiter, des procédés de traitement de troubles associés à la signalisation de PI3Kα avec les composés et les compositions de l'invention.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAJ8DT2PrdRwdPPw9PJM8Q_KFjB0c9Fwdc1xMPfJVjB300hNNhVIcTDNcjV342HgTUtMac4lRdKczMou7mGOHvophbkx6cWFyQmp-allsSH-xsZGBkbGRkYGhs6GhkTpwoAiDMmrA</recordid><startdate>20231116</startdate><enddate>20231116</enddate><creator>MCLEAN, Thomas H</creator><creator>FRIDRICH, Cary Griffin</creator><creator>PAN, Yue</creator><creator>MOHAMED, Tarek</creator><creator>RAYNOR, Kevin David</creator><creator>BURNIE, Andrew J</creator><creator>PERREAULT, Christian</creator><creator>BAUM, Erich W</creator><creator>SHORTSLEEVES, Kelley C</creator><creator>ATIENZA, Bren-Jordan</creator><creator>LARIVEE, Alexandre</creator><creator>BOEZIO, Alessandro</creator><creator>LEPITRE, Thomas</creator><creator>DENINNO, Michael Paul</creator><creator>KRUEGER, Elaine B</creator><creator>THOMSON, Christopher</creator><creator>MOUSTAKAS, Demetri T</creator><creator>MAERTENS, Gaetan</creator><scope>EVB</scope></search><sort><creationdate>20231116</creationdate><title>PI3Kα INHIBITORS AND METHODS OF USE THEREOF</title><author>MCLEAN, Thomas H ; FRIDRICH, Cary Griffin ; PAN, Yue ; MOHAMED, Tarek ; RAYNOR, Kevin David ; BURNIE, Andrew J ; PERREAULT, Christian ; BAUM, Erich W ; SHORTSLEEVES, Kelley C ; ATIENZA, Bren-Jordan ; LARIVEE, Alexandre ; BOEZIO, Alessandro ; LEPITRE, Thomas ; DENINNO, Michael Paul ; KRUEGER, Elaine B ; THOMSON, Christopher ; MOUSTAKAS, Demetri T ; MAERTENS, Gaetan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2023220131A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>MCLEAN, Thomas H</creatorcontrib><creatorcontrib>FRIDRICH, Cary Griffin</creatorcontrib><creatorcontrib>PAN, Yue</creatorcontrib><creatorcontrib>MOHAMED, Tarek</creatorcontrib><creatorcontrib>RAYNOR, Kevin David</creatorcontrib><creatorcontrib>BURNIE, Andrew J</creatorcontrib><creatorcontrib>PERREAULT, Christian</creatorcontrib><creatorcontrib>BAUM, Erich W</creatorcontrib><creatorcontrib>SHORTSLEEVES, Kelley C</creatorcontrib><creatorcontrib>ATIENZA, Bren-Jordan</creatorcontrib><creatorcontrib>LARIVEE, Alexandre</creatorcontrib><creatorcontrib>BOEZIO, Alessandro</creatorcontrib><creatorcontrib>LEPITRE, Thomas</creatorcontrib><creatorcontrib>DENINNO, Michael Paul</creatorcontrib><creatorcontrib>KRUEGER, Elaine B</creatorcontrib><creatorcontrib>THOMSON, Christopher</creatorcontrib><creatorcontrib>MOUSTAKAS, Demetri T</creatorcontrib><creatorcontrib>MAERTENS, Gaetan</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MCLEAN, Thomas H</au><au>FRIDRICH, Cary Griffin</au><au>PAN, Yue</au><au>MOHAMED, Tarek</au><au>RAYNOR, Kevin David</au><au>BURNIE, Andrew J</au><au>PERREAULT, Christian</au><au>BAUM, Erich W</au><au>SHORTSLEEVES, Kelley C</au><au>ATIENZA, Bren-Jordan</au><au>LARIVEE, Alexandre</au><au>BOEZIO, Alessandro</au><au>LEPITRE, Thomas</au><au>DENINNO, Michael Paul</au><au>KRUEGER, Elaine B</au><au>THOMSON, Christopher</au><au>MOUSTAKAS, Demetri T</au><au>MAERTENS, Gaetan</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PI3Kα INHIBITORS AND METHODS OF USE THEREOF</title><date>2023-11-16</date><risdate>2023</risdate><abstract>The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3Kα enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3Kα signaling with the compounds and compositions of the disclosure.
La présente invention concerne de nouveaux composés et des compositions pharmaceutiques de ceux-ci, et des procédés d'inhibition de l'activité d'enzymes PI3Kα avec les composés et les compositions de l'invention. La présente invention concerne en outre, mais sans s'y limiter, des procédés de traitement de troubles associés à la signalisation de PI3Kα avec les composés et les compositions de l'invention.</abstract><oa>free_for_read</oa></addata></record> |
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| title | PI3Kα INHIBITORS AND METHODS OF USE THEREOF |
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