PI3Kα INHIBITORS AND METHODS OF USE THEREOF

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3Kα enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders...

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Bibliographische Detailangaben
Hauptverfasser:	MCLEAN, Thomas H, FRIDRICH, Cary Griffin, PAN, Yue, MOHAMED, Tarek, RAYNOR, Kevin David, BURNIE, Andrew J, PERREAULT, Christian, BAUM, Erich W, SHORTSLEEVES, Kelley C, ATIENZA, Bren-Jordan, LARIVEE, Alexandre, BOEZIO, Alessandro, LEPITRE, Thomas, DENINNO, Michael Paul, KRUEGER, Elaine B, THOMSON, Christopher, MOUSTAKAS, Demetri T, MAERTENS, Gaetan
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3Kα enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3Kα signaling with the compounds and compositions of the disclosure. La présente invention concerne de nouveaux composés et des compositions pharmaceutiques de ceux-ci, et des procédés d'inhibition de l'activité d'enzymes PI3Kα avec les composés et les compositions de l'invention. La présente invention concerne en outre, mais sans s'y limiter, des procédés de traitement de troubles associés à la signalisation de PI3Kα avec les composés et les compositions de l'invention.