TYK2 INHIBITORS

This disclosure relates to compounds of formula (I), or pharmaceutically acceptable salts thereof: in which all of the variables are as defined in the application. The compounds of the present disclosure are capable of inhibiting the activity of tyrosine kinase 2 (TYK2). The disclosure further provi...

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Bibliographische Detailangaben
Hauptverfasser:	MAITRA, Soma, ZHANG, Lei, GENUNG, Nathan, VESSELS, Jeffrey, VANDEVEER, Harold, LEVIN, Tamara, LIN, Edward, GUCKIAN, Kevin, HELAL, Christopher, CHEN, TeYu, SCHULZ, Jürgen, VAN VLOTEN, Kurt, NEVALAINEN, Marta, LOPEZ DE TURISO, Felix, SCIABOLA, Simone, XIN, Zhili
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This disclosure relates to compounds of formula (I), or pharmaceutically acceptable salts thereof: in which all of the variables are as defined in the application. The compounds of the present disclosure are capable of inhibiting the activity of tyrosine kinase 2 (TYK2). The disclosure further provides methods of preparing the compounds of the disclosure, and methods for their therapeutic use. L'invention concerne des composés de formule (I), ou des sels pharmaceutiquement acceptables de ceux-ci, toutes les variables étant telles que définies dans la présente demande. Les composés de la présente invention sont capables d'inhiber l'activité de la tyrosine kinase 2 (TYK2). L'invention concerne en outre des procédés de préparation des composés de l'invention, et des procédés pour leur utilisation thérapeutique.