DNA-PK INHIBITOR COMPOUNDS AND USES THEREOF

Provided are compounds and method for inhibiting DNA-dependent protein kinase (DNA-PK). Aspects of the present disclosure also include methods of using the compounds to treat disease, including, but not limited to, cancer. In certain embodiments, the compounds inhibit DNA-PK and thus sensitize cance...

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Bibliographische Detailangaben
Hauptverfasser:	MINCHINTON, Andrew I, HSIEH, Tom Han Hsiao, SHIDMOOSSAVEE, Fahimeh S, YEE, Leanna, BAKER, Jennifer H.e, HAMBY, Callum, PAQUETTE, Jay John, ARNS, Stephen Paul, OSBORNE, Simon, TAN, Jason Samuel, KYLE, Alastair H
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided are compounds and method for inhibiting DNA-dependent protein kinase (DNA-PK). Aspects of the present disclosure also include methods of using the compounds to treat disease, including, but not limited to, cancer. In certain embodiments, the compounds inhibit DNA-PK and thus sensitize cancers to therapies such as chemotherapy and radiotherapy. Compounds provided are of Formula (I). L'invention concerne des composés et un procédé d'inhibition de la protéine kinase dépendante de l'ADN (ADN-PK). Des aspects de la présente divulgation concernent également des méthodes d'utilisation des composés pour traiter une maladie, notamment mais non exclusivement, le cancer. Dans certains modes de réalisation, les composés inhibent l'ADN-PK et sensibilisent ainsi les cancers à des thérapies telles qu'une chimiothérapie et une radiothérapie. Les composés selon l'invention sont de formule (I) :