MULTISPECIFIC ANTIBODIES TARGETING IL-13 AND IL-18

Described herein are multispecific antibodies targeting IL-13 and IL-18. The multispecific antibodies can be antagonistic and/or therapeutic antibodies targeting IL-13 and IL-18. Also described herein are methods of making said multispecific antibodies, methods of inhibiting IL- 13 and IL-18 simulta...

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Bibliographische Detailangaben
Hauptverfasser:	ROTH, Lukas, RITTER, Anett, KOLBINGER, Frank, CEBE, Regis, KOVARIK, Jiri, BARDROFF, Michael Otto, KIFFE, Michael
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Described herein are multispecific antibodies targeting IL-13 and IL-18. The multispecific antibodies can be antagonistic and/or therapeutic antibodies targeting IL-13 and IL-18. Also described herein are methods of making said multispecific antibodies, methods of inhibiting IL- 13 and IL-18 simultaneously with said multispecific antibodies, and methods of treating an IL- 13/IL-18 mediated disorder, such as atopic dermatitis, by administering a multispecific antibody described herein. L'invention concerne des anticorps multispécifiques ciblant IL-13 et IL-18. Les anticorps multispécifiques peuvent être des anticorps antagonistes et/ou thérapeutiques ciblant IL-13 et IL-18. L'invention concerne également des procédés de fabrication desdits anticorps multispécifiques, des procédés d'inhibition de l'IL-13 et de l'IL-18 simultanément avec lesdits anticorps multispécifiques, et des méthodes de traitement d'un trouble médié par IL-13/IL-18, tel que la dermatite atopique, par administration d'un anticorps multispécifique selon l'invention.