CONJUGATE COMPRISING TOLL-LIKE RECEPTOR AGONIST

Disclosed herein are compounds that are Toll-like receptor (TLR) agonist, conjugates comprising these compounds and cell targeting moiety, pharmaceutical compositions thereof, method of activating toll-like receptors 7 and/or 8 and method for the treatment of diseases or disorders mediated by toll-l...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN, Lianyong, ZHENG, Yong
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are compounds that are Toll-like receptor (TLR) agonist, conjugates comprising these compounds and cell targeting moiety, pharmaceutical compositions thereof, method of activating toll-like receptors 7 and/or 8 and method for the treatment of diseases or disorders mediated by toll-like receptors 7 and/or 8, in particular viral infections and proliferative disorders, such as cancer. L'invention concerne des composés qui sont un agoniste du récepteur de type Toll (TLR), des conjugués comprenant ces composés et une fraction de ciblage de cellules, des compositions pharmaceutiques associées, un procédé d'activation de récepteurs de type Toll 7 et/ou 8 et un procédé de traitement de maladies ou de troubles médiés par des récepteurs de type Toll 7 et/ou 8, en particulier des infections virales et des troubles prolifératifs, tels que le cancer.