SIX- AND SIX-MEMBERED COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION

Disclosed are a six- and six-membered compound, a preparation method, a pharmaceutical composition, and an application. Provided is a six- and six-membered compound as represented by formula (I) or a pharmaceutically acceptable salt thereof. The compound has a good inhibitory effect on KRAS G12D, an...

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Bibliographische Detailangaben
Hauptverfasser:	XIANG, Michael, ZHANG, Bing, WU, Lei, XIANG, Camille, YANG, Rui, XIANG, Jason Shaoyun, WANG, Suyue, LIU, Yuxin
Format:	Patent
Sprache:	chi ; eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are a six- and six-membered compound, a preparation method, a pharmaceutical composition, and an application. Provided is a six- and six-membered compound as represented by formula (I) or a pharmaceutically acceptable salt thereof. The compound has a good inhibitory effect on KRAS G12D, and can be used for treating tumors related to KRAS G12D. L'invention concerne un composé à six et six chaînons, un procédé de préparation, une composition pharmaceutique et une application. L'invention concerne un composé à six et six chaînons tel que représenté par la formule (I) ou un sel pharmaceutiquement acceptable de celui-ci. Le composé a un bon effet inhibiteur sur KRAS G12D, et peut être utilisé pour traiter des tumeurs associées à KRAS G12D. 公开了一种六元并六元化合物、制备方法、药物组合物和应用。提供了一种如式(I)所示的六元并六元化合物或其药学上可接受的盐，所述化合物对KRAS G12D有较好的抑制效果，可用于与KRAS G12D相关的肿瘤的治疗。