AMORPHOUS AND CRYSTALLINE FORMS OF MCI-1 ANTAGONISTS

Disclosed herein are crystalline and amorphous forms of (1S,3'R,6'R,7'S,8'E,11'S,12'R)-6-chloro-7'-methoxy-11',12'-dimethyl-3,4-dihydro-2H,15'H-spiro[naphthalene-1,22'-[20]oxa[13]thia[1,14]diazatetracyclo[14.7.2.03,6.019,24]pentacosa[8,16,18,24]...

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Bibliographische Detailangaben
Hauptverfasser:	REW, Yosup, ZANCANELLA, Manuel, CHAVES, Mary, LUU, Van
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are crystalline and amorphous forms of (1S,3'R,6'R,7'S,8'E,11'S,12'R)-6-chloro-7'-methoxy-11',12'-dimethyl-3,4-dihydro-2H,15'H-spiro[naphthalene-1,22'-[20]oxa[13]thia[1,14]diazatetracyclo[14.7.2.03,6.019,24]pentacosa[8,16,18,24]tetraen]-15'-one 13',13'-dioxide (AMG 176), and salts and hydrates thereof. Also disclosed are methods of making the crystalline and amorphous forms, and methods of treating diseases and disorders with the crystalline and amorphous forms. L'invention concerne des formes cristallines et amorphes de (1S,3'R,6'R,7'S,8'E,11'S,12'R)-6-chloro-7'-méthoxy-11',12'-diméthyl-3,4-dihydro-2H,15'H-spiro[naphtalène-1,22'-[20]oxa[13]thia[1,14]diazatétracyclo[14.7.2.03,6.019,24]pentacosa[8,16,18,24]tétraé]-15'-one 13',13'-dioxide (AMG 176) : et ses sels et hydrates de celles-ci. L'invention concerne également des procédés de fabrication des formes cristallines et amorphes, et des procédés de traitement de maladies et de troubles avec les formes cristallines et amorphes.