BUTYRATE ANALOGUES AND METHODS OF USE FOR HIF STABILIZATION AND TREATMENT OF BOWEL DISEASE

Compositions comprising butyric acid and derivatives thereof for a method of treating intestinal disease. These compositions act to stabilize HIF through the inhibition of PHDs. The disclosure teaches butyrate, and derivatives thereof, to bind and function as a unique, noncompetitive inhibitor of PH...

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Bibliographische Detailangaben
Hauptverfasser:	COLGAN, Sean P, ORNELAS-SANCHEZ, Alfredo, WANG, Ruth X
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compositions comprising butyric acid and derivatives thereof for a method of treating intestinal disease. These compositions act to stabilize HIF through the inhibition of PHDs. The disclosure teaches butyrate, and derivatives thereof, to bind and function as a unique, noncompetitive inhibitor of PHDs relative to other Short-chain fatty acids (SCFAs). L'invention concerne des compositions comprenant de l'acide butyrique et des dérivés de celui-ci pour une méthode de traitement d'une maladie intestinale. Ces compositions agissent pour stabiliser HIF par inhibition des PHD. L'invention permet d'amener le butyrate, et des dérivés de celui-ci, à se lier et à fonctionner comme un unique inhibiteur non compétitif des PDH par rapport aux autres acides gras à chaîne courte (SCFA).