PROCESS FOR THE PREPARATION OF PALBOCICLIB
The present invention relates to an improved process for the preparation of palbociclib. The present invention also relates to a novel crystalline Form G of tert-butyl 4-(6-{[6- (1-butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3- d]pyrimidin-2-yl]amino}pyridin-3-yl)piperazine-1-car...
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| creator | PALLE, Venkata Raghavendra Acharyulu HARATHI DWARAKANATH, Srinivas Harinath SHELKE, Shivaji LAD, Sachin PATLE, Girish PATEL, Pratik |
| description | The present invention relates to an improved process for the preparation of palbociclib. The present invention also relates to a novel crystalline Form G of tert-butyl 4-(6-{[6- (1-butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3- d]pyrimidin-2-yl]amino}pyridin-3-yl)piperazine-1-carboxylate (also known as N-BOC palbociclib), and a process for its preparation. The novel Form G of tert-butyl 4-(6-{[6- (1-butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3- d]pyrimidin-2-yl]amino}pyridin-3-yl)piperazine-1-carboxylate (also known as N-BOC palbociclib) is substantially in accordance with Firgure 1.
La présente invention concerne un procédé de préparation de palbociclib. La présente invention concerne également une nouvelle forme cristalline G de 4-(6-{[6- (1-butoxyéthenyl)-8-cyclopentyl-5-méthyl-7-oxo-7,8-dihydropyrido[2,3- d]pyrimidin-2-yl]amino}pyridin-3-yl)pipérazine-1-carboxylate tert-butylique (également connu sous le nom de N-BOC palbociclib), et son procédé de préparation. La nouvelle forme G de 4-(6-{[6- (1-butoxyéthenyl)-8-cyclopentyl-5-méthyl-7-oxo-7,8-dihydropyrido[2,3- d]pyrimidin-2-yl]amino}pyridin-3-yl)pipérazine-1-carboxylate tert-butylique (également connu sous le nom de N-BOC palbociclib) est sensiblement conforme à la figure 1. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_WO2023194870A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>WO2023194870A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_WO2023194870A13</originalsourceid><addsrcrecordid>eNrjZNAKCPJ3dg0OVnDzD1II8XBVCAhyDXAMcgzx9PdT8HdTCHD0cfJ39nT28XTiYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBkbGhpYmFuYGjobGxKkCANpDJX4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PROCESS FOR THE PREPARATION OF PALBOCICLIB</title><source>esp@cenet</source><creator>PALLE, Venkata Raghavendra Acharyulu ; HARATHI DWARAKANATH, Srinivas Harinath ; SHELKE, Shivaji ; LAD, Sachin ; PATLE, Girish ; PATEL, Pratik</creator><creatorcontrib>PALLE, Venkata Raghavendra Acharyulu ; HARATHI DWARAKANATH, Srinivas Harinath ; SHELKE, Shivaji ; LAD, Sachin ; PATLE, Girish ; PATEL, Pratik</creatorcontrib><description>The present invention relates to an improved process for the preparation of palbociclib. The present invention also relates to a novel crystalline Form G of tert-butyl 4-(6-{[6- (1-butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3- d]pyrimidin-2-yl]amino}pyridin-3-yl)piperazine-1-carboxylate (also known as N-BOC palbociclib), and a process for its preparation. The novel Form G of tert-butyl 4-(6-{[6- (1-butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3- d]pyrimidin-2-yl]amino}pyridin-3-yl)piperazine-1-carboxylate (also known as N-BOC palbociclib) is substantially in accordance with Firgure 1.
La présente invention concerne un procédé de préparation de palbociclib. La présente invention concerne également une nouvelle forme cristalline G de 4-(6-{[6- (1-butoxyéthenyl)-8-cyclopentyl-5-méthyl-7-oxo-7,8-dihydropyrido[2,3- d]pyrimidin-2-yl]amino}pyridin-3-yl)pipérazine-1-carboxylate tert-butylique (également connu sous le nom de N-BOC palbociclib), et son procédé de préparation. La nouvelle forme G de 4-(6-{[6- (1-butoxyéthenyl)-8-cyclopentyl-5-méthyl-7-oxo-7,8-dihydropyrido[2,3- d]pyrimidin-2-yl]amino}pyridin-3-yl)pipérazine-1-carboxylate tert-butylique (également connu sous le nom de N-BOC palbociclib) est sensiblement conforme à la figure 1.</description><language>eng ; fre</language><subject>APPARATUS THEREFOR ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231012&DB=EPODOC&CC=WO&NR=2023194870A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231012&DB=EPODOC&CC=WO&NR=2023194870A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PALLE, Venkata Raghavendra Acharyulu</creatorcontrib><creatorcontrib>HARATHI DWARAKANATH, Srinivas Harinath</creatorcontrib><creatorcontrib>SHELKE, Shivaji</creatorcontrib><creatorcontrib>LAD, Sachin</creatorcontrib><creatorcontrib>PATLE, Girish</creatorcontrib><creatorcontrib>PATEL, Pratik</creatorcontrib><title>PROCESS FOR THE PREPARATION OF PALBOCICLIB</title><description>The present invention relates to an improved process for the preparation of palbociclib. The present invention also relates to a novel crystalline Form G of tert-butyl 4-(6-{[6- (1-butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3- d]pyrimidin-2-yl]amino}pyridin-3-yl)piperazine-1-carboxylate (also known as N-BOC palbociclib), and a process for its preparation. The novel Form G of tert-butyl 4-(6-{[6- (1-butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3- d]pyrimidin-2-yl]amino}pyridin-3-yl)piperazine-1-carboxylate (also known as N-BOC palbociclib) is substantially in accordance with Firgure 1.
La présente invention concerne un procédé de préparation de palbociclib. La présente invention concerne également une nouvelle forme cristalline G de 4-(6-{[6- (1-butoxyéthenyl)-8-cyclopentyl-5-méthyl-7-oxo-7,8-dihydropyrido[2,3- d]pyrimidin-2-yl]amino}pyridin-3-yl)pipérazine-1-carboxylate tert-butylique (également connu sous le nom de N-BOC palbociclib), et son procédé de préparation. La nouvelle forme G de 4-(6-{[6- (1-butoxyéthenyl)-8-cyclopentyl-5-méthyl-7-oxo-7,8-dihydropyrido[2,3- d]pyrimidin-2-yl]amino}pyridin-3-yl)pipérazine-1-carboxylate tert-butylique (également connu sous le nom de N-BOC palbociclib) est sensiblement conforme à la figure 1.</description><subject>APPARATUS THEREFOR</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAKCPJ3dg0OVnDzD1II8XBVCAhyDXAMcgzx9PdT8HdTCHD0cfJ39nT28XTiYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx4f5GBkbGhpYmFuYGjobGxKkCANpDJX4</recordid><startdate>20231012</startdate><enddate>20231012</enddate><creator>PALLE, Venkata Raghavendra Acharyulu</creator><creator>HARATHI DWARAKANATH, Srinivas Harinath</creator><creator>SHELKE, Shivaji</creator><creator>LAD, Sachin</creator><creator>PATLE, Girish</creator><creator>PATEL, Pratik</creator><scope>EVB</scope></search><sort><creationdate>20231012</creationdate><title>PROCESS FOR THE PREPARATION OF PALBOCICLIB</title><author>PALLE, Venkata Raghavendra Acharyulu ; HARATHI DWARAKANATH, Srinivas Harinath ; SHELKE, Shivaji ; LAD, Sachin ; PATLE, Girish ; PATEL, Pratik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2023194870A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2023</creationdate><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>PALLE, Venkata Raghavendra Acharyulu</creatorcontrib><creatorcontrib>HARATHI DWARAKANATH, Srinivas Harinath</creatorcontrib><creatorcontrib>SHELKE, Shivaji</creatorcontrib><creatorcontrib>LAD, Sachin</creatorcontrib><creatorcontrib>PATLE, Girish</creatorcontrib><creatorcontrib>PATEL, Pratik</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PALLE, Venkata Raghavendra Acharyulu</au><au>HARATHI DWARAKANATH, Srinivas Harinath</au><au>SHELKE, Shivaji</au><au>LAD, Sachin</au><au>PATLE, Girish</au><au>PATEL, Pratik</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR THE PREPARATION OF PALBOCICLIB</title><date>2023-10-12</date><risdate>2023</risdate><abstract>The present invention relates to an improved process for the preparation of palbociclib. The present invention also relates to a novel crystalline Form G of tert-butyl 4-(6-{[6- (1-butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3- d]pyrimidin-2-yl]amino}pyridin-3-yl)piperazine-1-carboxylate (also known as N-BOC palbociclib), and a process for its preparation. The novel Form G of tert-butyl 4-(6-{[6- (1-butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3- d]pyrimidin-2-yl]amino}pyridin-3-yl)piperazine-1-carboxylate (also known as N-BOC palbociclib) is substantially in accordance with Firgure 1.
La présente invention concerne un procédé de préparation de palbociclib. La présente invention concerne également une nouvelle forme cristalline G de 4-(6-{[6- (1-butoxyéthenyl)-8-cyclopentyl-5-méthyl-7-oxo-7,8-dihydropyrido[2,3- d]pyrimidin-2-yl]amino}pyridin-3-yl)pipérazine-1-carboxylate tert-butylique (également connu sous le nom de N-BOC palbociclib), et son procédé de préparation. La nouvelle forme G de 4-(6-{[6- (1-butoxyéthenyl)-8-cyclopentyl-5-méthyl-7-oxo-7,8-dihydropyrido[2,3- d]pyrimidin-2-yl]amino}pyridin-3-yl)pipérazine-1-carboxylate tert-butylique (également connu sous le nom de N-BOC palbociclib) est sensiblement conforme à la figure 1.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PROCESS FOR THE PREPARATION OF PALBOCICLIB |
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