ANTAGONISTS OF HUMAN MICRO RNA MIR-100, MIR-20, MIR-222, MIR-181 AND MIR-92 AND USES OF SAME

Disclosed are antagonists of human micro RNA miR-100, miR-20, miR-222, miR-181 and miR-92 and uses of same. The invention provides inhibitors of human micro-RNA miR-100, miR-20a, miR-222, miR-181c and miR-92a, which are repressors of the genes MBNL1 and/or MBNL2. The use of the inhibitors as a drug,...

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Bibliographische Detailangaben
Hauptverfasser:	MORENO CERVERA, Nerea, OVERBY, Sarah Joann, ARTERO ALLEPUZ, Rubén Darío, CERRO HERREROS, Estefanía, LLAMUSÍ TROISI, Beatriz, GONZÁLEZ MARTÍNEZ, Irene
Format:	Patent
Sprache:	eng ; fre ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed are antagonists of human micro RNA miR-100, miR-20, miR-222, miR-181 and miR-92 and uses of same. The invention provides inhibitors of human micro-RNA miR-100, miR-20a, miR-222, miR-181c and miR-92a, which are repressors of the genes MBNL1 and/or MBNL2. The use of the inhibitors as a drug, in particular against myotonic dystrophy type 1, is also provided. La invención proporciona inhibidores de los microRNA humanos miR-100, miR-20a, miR-5 222, miR-181c, o miR-92a que son represores de los genes MBNL1 y/o MBNL2, y el uso de dichos inhibidores como medicamento, especialmente frente a distrofia miotónica tipo 1. L'invention concerne des inhibiteurs des microARN humains miR-100, miR-20, miR-222, miR-181 ou miR-92 qui sont des répresseurs des gènes MBNL1 et/ou MBNL2, ainsi que l'utilisation desdits inhibiteurs comme médicament, notamment contre la dystrophie myotonique de type 1.