METHODS OF TREATING, AMELIORATING AND/OR PREVENTING FIBRODYSPLASIA OSSIFICANS PROGRESSIVA AND HETEROTOPIC OSSIFICATION, AND KITS FOR THE SAME

Disclosed herein are methods for treating, ameliorating and/or preventing fibrodysplasia sssificans progressiva (FOP) in a subject in need thereof. The methods include downregulating matrix metalloproteinase 9 (MMP-9) level and/or activity in the subject. Also disclosed are kits for carrying out the...

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Bibliographische Detailangaben
Hauptverfasser:	PIGNOLO, Robert J, KAPLAN, Frederick S, LOUNEV, Vitali
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed herein are methods for treating, ameliorating and/or preventing fibrodysplasia sssificans progressiva (FOP) in a subject in need thereof. The methods include downregulating matrix metalloproteinase 9 (MMP-9) level and/or activity in the subject. Also disclosed are kits for carrying out the methods disclosed herein. L'invention concerne des méthodes de traitement, d'amélioration et/ou de prévention de la fibrodysplasie ossifiante progressive (FOP) chez un sujet en ayant besoin. Les procédés comprennent la régulation à la baisse du niveau et/ou de l'activité de la métalloprotéinase matricielle 9 (MMP -9) chez le sujet. L'invention concerne également des kits permettant de mettre en œuvre les procédés de l'invention.