ANTIBODY BINDING TO NOVEL CORONAVIRUS (SARS-COV-2)

The present invention addresses the problem of providing a novel antibody that can prevent and/or treat COVID-19 infection. One aspect of the present invention provides: an antibody which has a heavy-chain CDR1 comprising the amino acid sequence of SEQ ID NO: 1, a heavy-chain CDR2 comprising the ami...

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Bibliographische Detailangaben
Hauptverfasser:	SATO Shigeko, WATANABE Shinya, IMAI Junichi, HOSHI Hirotaka, SHIGA Hatsuki, MATSUKURA Susumu
Format:	Patent
Sprache:	eng ; fre ; jpn
Schlagworte:	ACCESSORIES BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DEVICES, APPARATUS OR METHODS FOR LIFE-SAVING ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FIRE-FIGHTING FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE LIFE-SAVING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY OUTERWEAR PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS PROTECTIVE GARMENTS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS SPIRITS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES VINEGAR WEARING APPAREL WINE
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Beschreibung
Zusammenfassung:	The present invention addresses the problem of providing a novel antibody that can prevent and/or treat COVID-19 infection. One aspect of the present invention provides: an antibody which has a heavy-chain CDR1 comprising the amino acid sequence of SEQ ID NO: 1, a heavy-chain CDR2 comprising the amino acid sequence of SEQ ID NO: 2, a heavy-chain CDR3 comprising the amino acid sequence of SEQ ID NO: 3, a light-chain CDR1 comprising the amino acid sequence of SEQ ID NO: 4, a light-chain CDR2 comprising the amino acid sequence of SEQ ID NO: 5, and a light-chain CDR3 comprising the amino acid sequence of SEQ ID NO: 6, and which binds to an S1 subunit of SARS-CoV-2; or a fragment of said antibody. La présente invention pour but de procurer un nouvel anticorps pouvant prévenir et/ou traiter l'infection par le COVID-19. Un aspect de la présente invention concerne : un anticorps présentant un CDR1 à chaîne lourde comprenant la séquence d'acides aminés de SEQ. ID NO : 1, un CDR2 à chaîne lourde comprenant la séquence d'acides aminés de SEQ ID NO : 2, un CDR3 à chaîne lourde comprenant la séquence d'acides aminés de SEQ ID NO : 3, un CDR1 de la chaîne légère comprenant la séquence d'acides aminés de SEQ ID NO : 4, un CDR2 de la chaîne légère comprenant la séquence d'acides aminés de SEQ ID NO : 5, et un CDR3 de la chaîne légère comprenant la séquence d'acides aminés de SEQ ID NO : 6, et se liant à une sous-unité S1 du SARS-CoV-2 ; ou un fragment de cet anticorps. 本発明は、COVID-19に対する感染予防および／または治療を可能とする新規抗体の提供を課題とする。本発明の一態様は、配列番号１のアミノ酸配列からなる重鎖CDR１、配列番号２のアミノ酸配列からなる重鎖CDR2、配列番号３のアミノ酸配列からなる重鎖CDR3、配列番号４のアミノ酸配列からなる軽鎖CDR1、配列番号５のアミノ酸配列からなる軽鎖CDR2、および、配列番号６のアミノ酸配列からなる軽鎖CDR3を有する抗体であって、SARS-CoV-2のS1サブユニットに結合する、抗体またはその抗体フラグメントを提供する。