PROCESS FOR PREPARING ( (1S, 2S) -2- (5-METHYLPYRIDIN-2-YL) CYCLOPROPYL) -METHANOL

PROCESS FOR PREPARING ( (1S, 2S) -2- (5-METHYLPYRIDIN-2-YL) CYCLOPROPYL) -METHANOL

Providing an efficient scalable synthesis of compounds of formula 5', such as ((1S, 2S)-2-(5-methylpyridin-2-yl) cyclo-propyl) methanol, which contains a disubstituted cyclopropane with two stereogenic centers and represents a significant challenging synthetic target. L'invention concerne...

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Bibliographische Detailangaben
Hauptverfasser: LI, Donglin, SHANG, Gao, SNEAD, David R, XIAO, Chengqian, GIBSON, Andrew W, CHUNG, John Y. L, ZHAO, Xiaxia, LIEBERMAN, David R, LÉVESQUE, François, ZHAO, Zhenbing, TAN, Lushi
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Providing an efficient scalable synthesis of compounds of formula 5', such as ((1S, 2S)-2-(5-methylpyridin-2-yl) cyclo-propyl) methanol, which contains a disubstituted cyclopropane with two stereogenic centers and represents a significant challenging synthetic target. L'invention concerne la fourniture d'une synthèse évolutive efficace de composés de formule 5', tels que le ((1S, 2S)-2-(5-méthylpyridin-2-yl)cyclo-propyl)méthanol, qui contient un cyclopropane disubstitué avec deux centres stéréogènes et représente une cible synthétique de test de provocation significative.