SPLEEN TYROSINE KINASE INHIBITOR, COMPOSITION, AND METHODS OF USE

Compounds, compositions and methods for inhibiting Syk from phosphorylating erythrocyte anion transporter band 3 and/or Syk tyrosine kinase. Further disclosed are methods of treating a subject for a disease involving the release of microvesicles from blood cells, including alpha-thalassemia or beta-...

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Hauptverfasser:	HAUSMAN, John, SRINIVASARAO, Madduri, LOW, Philip, YARLAGADDA, Suresh
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds, compositions and methods for inhibiting Syk from phosphorylating erythrocyte anion transporter band 3 and/or Syk tyrosine kinase. Further disclosed are methods of treating a subject for a disease involving the release of microvesicles from blood cells, including alpha-thalassemia or beta-thalassemia, sickle cell disease, glucose-6-phosphate dehydrogenase (G6PD) deficiency or glutathione reductase deficiency. L'invention concerne des composés, des compositions et des procédés permettant d'empêcher la Syk de phosphoryler la bande transporteuse d'anions érythrocytaires 3 et/ou la tyrosine kinase Syk.