EGFRVIII-SPECIFIC APTAMER AND USES THEREOF

The present invention relates to an epidermal growth factor receptor variant III (EGFRvIII) specific aptamer and to the detection of EGFRvIII or the diagnosis of cancer using same. Since the aptamer of the present invention binds to EGFRvIII with high affinity, the aptamer can be applied to detect E...

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Bibliographische Detailangaben
Hauptverfasser:	KANG, Juhyung, SHIN, Euisu, KIM, Youndong, LEE, Daekyun, LEE, Dasom
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to an epidermal growth factor receptor variant III (EGFRvIII) specific aptamer and to the detection of EGFRvIII or the diagnosis of cancer using same. Since the aptamer of the present invention binds to EGFRvIII with high affinity, the aptamer can be applied to detect EGFRvIII or diagnose EGFRvIII-expressing cancer. La présente invention concerne un aptamère spécifique du variant III du récepteur du facteur de croissance épidermique (EGFRvIII) et la détection de l'EGFRvIII ou le diagnostic du cancer à l'aide de celui-ci. Étant donné que l'aptamère de la présente invention se lie à l'EGFRvIII avec une grande affinité, l'aptamère peut être utilisé pour détecter l'EGFRvIII ou diagnostiquer un cancer exprimant l'EGFRvIII. 본 발명은 EGFRvIII (epidermal growth factor receptor variant III) 특이적 압타머 및 이를 이용한 EGFRvIII 검출 또는 암 진단에 관한 것으로, 본 발명의 압타머는 EGFRvIII에 대해 높은 결합력으로 결합하므로 EGFRvIII 검출 또는 EGFRvIII를 발현하는 암의 진단에 적용할 수 있다.