PYRROLOBENZODIAZEPINE INTERMEDIATES AND USES THEREOF

Pyrrolobenzodiazepine (PBD) intermediates, including useful in the preparation of advanced intermediates, PBDs, and PBD dimers. Such PBD intermediates provide several advantages, including simplified synthesis of desired PBD products, greater substrate compatibility, and safer reaction conditions. L...

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Bibliographische Detailangaben
Hauptverfasser:	AIWALE, Sachin, GROSO, Emilia, WALKER, James, WRIGHT, Austin, SINGH, Ravindra, BEMOWSKI, Ross, BERG, Logan, P T, Sheshagiri, REDFERN, Louis, GOEDDEL, David
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Pyrrolobenzodiazepine (PBD) intermediates, including useful in the preparation of advanced intermediates, PBDs, and PBD dimers. Such PBD intermediates provide several advantages, including simplified synthesis of desired PBD products, greater substrate compatibility, and safer reaction conditions. L'invention concerne des intermédiaires de pyrrolobenzodiazépine (PBD), notamment utiles dans la préparation d'intermédiaires, de PBD et de dimères PBD avancés. De tels intermédiaires de PBD offrent plusieurs avantages, notamment la synthèse simplifiée de produits de PBD souhaités, une plus grande compatibilité de substrat et des conditions de réaction plus sûres.