COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING GPC3 SPECIFIC FUSION PROTEINS

Provided herein are T cell receptor (TCR) fusion proteins (TFPs) comprising GPC3 binding domains, T cells engineered to express one or more TFPs, and methods of use thereof for the treatment of diseases, including cancer. La présente invention concerne des protéines de fusion (TFP) du récepteur des...

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Hauptverfasser:	ASHMINOVA, Vania, DING, Jian, LOFGREN, Michael, YANG, Huan, TIGHE, Robert, HOFMEISTER, Robert, GUTIERREZ, Dario, HANES, Melinda
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein are T cell receptor (TCR) fusion proteins (TFPs) comprising GPC3 binding domains, T cells engineered to express one or more TFPs, and methods of use thereof for the treatment of diseases, including cancer. La présente invention concerne des protéines de fusion (TFP) du récepteur des lymphocytes T (TCR) comprenant des domaines de liaison à GPC3, des lymphocytes T modifiés pour exprimer une ou plusieurs TFP, ainsi que des méthodes d'utilisation associés pour le traitement de maladies, notamment du cancer.