METABOLIC SELECTION VIA THE ASPARAGINE BIOSYNTHESIS PATHWAY

The present disclosure provides an isolated mammalian cell comprising a reduced or eliminated expression of Asparagine Synthetase (ASNS). Further provided are methods for preparing such cells and methods for using such cells for the production of recombinant proteins. La présente divulgation concern...

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Bibliographische Detailangaben
Hauptverfasser:	OTTO, Mary, RAVELLETTE, James, RAZAFSKY, David, GUSTIN, Jason A, BORGSCHULTE, Trissa
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure provides an isolated mammalian cell comprising a reduced or eliminated expression of Asparagine Synthetase (ASNS). Further provided are methods for preparing such cells and methods for using such cells for the production of recombinant proteins. La présente divulgation concerne une cellule de mammifère isolée comprenant une expression réduite ou supprimée de l'asparagine synthétase (ASNS). La présente invention concerne également des procédés de préparation de ces cellules et des procédés d'utilisation de ces cellules pour la production de protéines de recombinaison.